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Identifies a component of smooth muscle myosin, a protein expressed in cells and tumors showing smooth muscle or myoepithelial differentiation. This antibody reacts with human visceral and vascular smooth muscle cells and myoepithelial cells and is useful in distinguishing between benign sclerosing breast leasons and infiltrating carcinomas because it strongly stains the myoepithelial layer in the benign lesions while being negative in the infiltrating carcinomas.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.