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Identifies SOX10, a highly specific and sensitive nuclear transcription factor expressed in nerve sheath tumors and melanomas, including conventional, spindle, and desmoplastic types. It is also seen in salivary gland and soft tissue tumors with myoepithelial differentiation, and is diffusely expressed in schwannoma, neurofibroma, and granular cell tumors. SOX10 is more specific than S100 and rarely expressed in other mesenchymal or epithelial tumors.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.