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Identifies a transcription factor expressed in almost all cases of mantle cell lymphoma (MCL) including cyclin D1-negative MCL. Routine use of anti-SOX11 in cases of suspected CD5+ diffuse large B cell lymphoma might help identify additional cases of cyclin D1-negative blastoid MCL. It is not expressed in potential MCL mimics such as atypical chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, and marginal zone lymphoma.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.