Thrombomodulin (CD 141)

Identifies a plasma membrane-associated glycoprotein expressed on endothelial cells and in other cell types, including megakaryocytes, mesangial cells, synovial cells, mesothelial cells, and some squamous epithelia. It serves as a marker for endothelial cells, vascular neoplasms, urinary bladder epithelium, and aids in distinguishing mesothelioma from adenocarcinoma. In mesotheliomas, staining is typically thick and membranous, while approximately half of pulmonary adenocarcinomas show cytoplasmic staining.