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Bi-directional sequencing analysis of TP53 gene in exons 4-9. TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor prognosis. It aids in prognosis and/or therapy selection in patients with chronic lymphocytic leukemia (CLL) and germline mutations in TP53 are the cause of Li-Fraumeni Syndrome.
Whole blood (3-5 mL), Bone marrow (1-2 mL), in Lavender-top (EDTA) tube.
Formalin-fixed,paraffin-embedded (FFPE) tissue block (preferred) or slides (1 H&E slide,plus 5-10 unstained slides cut at 5+ microns). Please use positively charged slides and 10% NBF fixative. Do not use zinc fixatives.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen. Do not freeze.