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Identifies tyrosinase, a copper-containing enzyme critical for melanin production, expressed in melanocytic cells and tumors. Mutations in this gene are associated with forms of albinism, and it serves as a target for cytotoxic T-cell recognition in melanoma. Staining detects both melanotic and amelanotic melanoma variants.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.