.png)
Identifies a transmembrane protein specific to urothelial cells, serving as a marker of transitional cell epithelium and tumors. In normal urothelium, UPIII is expressed on the luminal surface of superficial cells. It is highly specific but only moderately sensitive for detecting urothelial carcinomas and may reflect malignant potential.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.